Exo1<tm1Wed> Targeted Allele Detail MGI Mouse (MGI:2653925)

Exo1^tm1Wed
Targeted Allele Detail

Summary

Symbol:	Exo1^tm1Wed
Name:	exonuclease 1; targeted mutation 1, Winfried Edelmann
MGI ID:	MGI:2653925
Synonyms:	Exo1-, Exo1^mut
Gene:	Exo1 Location: Chr1:175708334-175738962 bp, + strand Genetic Position: Chr1, 81.9 cM
Alliance:	Exo1^tm1Wed page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:82426
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A hygromycin resistance gene cassette was inserted into exon 6 via homologous recombination resulting in disruption of the I-nuclease domain. Disruption of exon 6 in homozygous mutant ES cells was confirmed by northern and Western blot analysis. (J:82426)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Exo1^tm1Wed

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Exo1 Mutation:	46 strains or lines available

References

Original:	J:82426 Wei K, et al., Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev. 2003 Mar 1;17(5):603-14
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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