Ddit3<tm1Dron> Targeted Allele Detail MGI Mouse (MGI:2654034)

Ddit3^tm1Dron
Targeted Allele Detail

Summary

Symbol:	Ddit3^tm1Dron
Name:	DNA-damage inducible transcript 3; targeted mutation 1, David Ron
MGI ID:	MGI:2654034
Synonyms:	chop-, Chop null
Gene:	Ddit3 Location: Chr10:127126662-127132160 bp, + strand Genetic Position: Chr10, 74.5 cM
Alliance:	Ddit3^tm1Dron page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:52729
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced the coding region in parts of exons 3 and 4. Northern blot analyses did not detect transcript in MEFs from homozygous mutant E13.5 embryos. (J:52729)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

3 assay results
1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ddit3 Mutation:	20 strains or lines available

References

Original:	J:52729 Zinszner H, et al., CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998 Apr 1;12(7):982-95
All:	37 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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