About   Help   FAQ
Sox21 Gene Detail
Summary
  • Symbol
    Sox21
  • Name
    SRY (sex determining region Y)-box 21
  • Synonyms
    Sox25
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654070
    NCBI Gene: 223227
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118470645-118474442 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 61.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2654070
 protein coding gene Chr14:118470644-118474442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021649
 protein coding gene Chr14:115807733-115811531 (-)
A/J MGP_AJ_G0021608
 protein coding gene Chr14:111393058-111396856 (-)
AKR/J MGP_AKRJ_G0021584
 protein coding gene Chr14:115007381-115011179 (-)
BALB/cJ MGP_BALBcJ_G0021614
 protein coding gene Chr14:111933272-111937070 (-)
C3H/HeJ MGP_C3HHeJ_G0021392
 protein coding gene Chr14:114883015-114886813 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022054
 protein coding gene Chr14:120308603-120312401 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019593
 protein coding gene Chr14:107457711-107461526 (-)
CAST/EiJ MGP_CASTEiJ_G0020908
 protein coding gene Chr14:112718304-112722101 (-)
CBA/J MGP_CBAJ_G0021360
 protein coding gene Chr14:124923186-124926984 (-)
DBA/2J MGP_DBA2J_G0021483
 protein coding gene Chr14:111312660-111316458 (-)
FVB/NJ MGP_FVBNJ_G0021461
 protein coding gene Chr14:109647075-109650878 (-)
LP/J MGP_LPJ_G0021551
 protein coding gene Chr14:116840694-116844733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021488
 protein coding gene Chr14:130004077-130007875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022077
 protein coding gene Chr14:114471787-114475586 (-)
PWK/PhJ MGP_PWKPhJ_G0020652
 protein coding gene Chr14:108300854-108304642 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020490
 protein coding gene Chr14:110721232-110725030 (-)
WSB/EiJ MGP_WSBEiJ_G0020963
 protein coding gene Chr14:115275061-115278857 (-)



Homology
more
  • Human Ortholog
    SOX21, SRY-box transcription factor 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX21, SRY-box transcription factor 21
  • Synonyms
    SOX25
  • Links
    NCBI Gene ID: 11166
    neXtProt AC: NX_Q9Y651
    UniProt: Q9Y651

  • Chr Location
    13q32.1; chr13:94709622-94712545 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display cyclic alopecia, epidermal hyperplasia, enlarged sebaceous glands, and hair shaft and cuticle abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    93
  • cDNA Data
    18
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223227 NCBI Gene Model | MGI Sequence Detail 3798 C57BL/6J ±  kb
    transcript NM_177753 RefSeq | MGI Sequence Detail 3798 C57BL/6  
    polypeptide Q811W0 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 2
      cDNA 18
      Primer pair 8
      Other 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 34
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:355488 Erjavec E, et al., Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia. Am J Hum Genet. 2024 Oct 3;111(10):2265-2282
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory