Cav1tm1Tt
Targeted Allele Detail
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| Symbol: |
Cav1tm1Tt |
| Name: |
caveolin 1, caveolae protein; targeted mutation 1, Timothy C Thompson |
| MGI ID: |
MGI:2654177 |
| Synonyms: |
cav-1-, Cav1- |
| Gene: |
Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
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| Alliance: |
Cav1tm1Tt page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:82490
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| Parent Cell Line: |
AB2.2 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed neo cassette and loxP site were introduced flanking exon 2 via homologous recombination. Transient expression of cre-recombinase in correctly targeted ES cells resulted in deletion of exon 2 and the neo cassette leaving behind a single loxP site. Absence of protein product in homozygous mutant animals was confirmed by Western blot anlysis of heart, spleen, and lung extracts.
(J:82490)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cav1 Mutation: |
31 strains or lines available
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| Original: |
J:82490 Cao G, et al., Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 2003 Apr;162(4):1241-8 |
| All: |
7 reference(s) |
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Analysis Tools
