Scarb2<tm1Psa> Targeted Allele Detail MGI Mouse (MGI:2654430)

Scarb2^tm1Psa
Targeted Allele Detail

Summary

Symbol:	Scarb2^tm1Psa
Name:	scavenger receptor class B, member 2; targeted mutation 1, Paul Saftig
MGI ID:	MGI:2654430
Synonyms:	LIMP-2^-, LIMP2^-, LIMP-2 KO
Gene:	Scarb2 Location: Chr5:92589170-92653516 bp, - strand Genetic Position: Chr5, 46.82 cM, cytoband E3
Alliance:	Scarb2^tm1Psa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:82474
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The gene was disrupted by insertion of a neo cassette into exon 8 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR and Western blot analysis. (J:82474)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Scarb2 Mutation:	64 strains or lines available

References

Original:	J:82474 Gamp AC, et al., LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet. 2003 Mar 15;12(6):631-46
All:	11 reference(s)

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