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Foxp3tm1.1Ayr
Targeted Allele Detail
Summary
Symbol: Foxp3tm1.1Ayr
Name: forkhead box P3; targeted mutation 1.1, Alexander Y Rudensky
MGI ID: MGI:2654936
Synonyms: Foxp3-, Foxp3 KO
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance: Foxp3tm1.1Ayr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82560
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A floxed fragment encompassing exons 1 through 5 was deleted via cre mediated recombination in the germline. (J:82560)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  58 strains or lines available
References
Original:  J:82560 Fontenot JD, et al., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003 Apr;4(4):330-6
All:  49 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory