Hbegftm1Mek
Targeted Allele Detail
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| Symbol: |
Hbegftm1Mek |
| Name: |
heparin-binding EGF-like growth factor; targeted mutation 1, Eisuke Mekada |
| MGI ID: |
MGI:2655700 |
| Synonyms: |
Dtrtm1(lox), Hbegflox, HBlox |
| Gene: |
Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
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| Alliance: |
Hbegftm1Mek page
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: The wild-type mouse Hbegf cDNA, including the polyadenylation signal and flanked by loxP sites, is joined to the beginning of the first exon of the endogenous gene so that its expression is driven by the native promoter. The rest of exon 1 through exon 3 and most of intron 3 have been deleted. Downstream of the Hbegf cDNA are the bacterial beta-galactosidase gene (lacZ), with a polyadenylation signal and a nuclear targeting sequence, and the neomycin resistance gene driven by the phosphoglycerate kinase promoter, also with polyadenylation signal (Pgk-neo cassette), separated by a short segment from the middle of the third intron of the native gene. The lacZ gene is not expressed from this transgene.
(J:82728)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:82728 Iwamoto R, et al., Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6 |
| All: |
17 reference(s) |
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Analysis Tools
