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Iapptm1Sgm
Targeted Allele Detail
Summary
Symbol: Iapptm1Sgm
Name: islet amyloid polypeptide; targeted mutation 1, Samuel Gebre-Medhin
MGI ID: MGI:2656235
Synonyms: Amylin -, IAPP-
Gene: Iapp  Location: Chr6:142244151-142249546 bp, + strand  Genetic Position: Chr6, 73.81 cM
Alliance: Iapptm1Sgm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50042
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of islet cells from homozygous mutant animals. (J:50042)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Iapp Mutation:  14 strains or lines available
References
Original:  J:50042 Gebre-Medhin S, et al., Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin). Biochem Biophys Res Commun. 1998 Sep 18;250(2):271-7
All:  18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory