Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(GFAP-cre)8Gtm
Name:	transgene insertion 8, David H Gutmann
MGI ID:	MGI:2656248
Synonyms:	GFAP-Cre, GFAPCre, GFAP-Cre-IRES-LacZ
Transgene:	Tg(GFAP-cre)8Gtm  Location: unknown
Alliance:	Tg(GFAP-cre)8Gtm page

Strain of Origin:

C57BL/6 x CBA

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(GFAP-cre)8Gtm expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human GFAP (2670) Gfap  (MGI:95697)   Mutation details: This transgene expresses Cre recombinase and beta-galactosidase under the control of the human glial fibrillary acidic (GFAP) promoter. This transgene is expressed in astrocytes by embryonic day 14.5. Two lines 1 and 8 were analyzed further for cre activity and expression. Both gave identical results, with data for line 8 presented in the reference. (J:77208, J:185602)

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Comparative matrix view of recombinase activities Alliance human GFAP gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(GFAP-cre)8Gtm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:77208 Bajenaru ML, et al., Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol. 2002 Jul;22(14):5100-13
All:	53 reference(s)