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Myh11tm1Bdr
Targeted Allele Detail
Summary
Symbol: Myh11tm1Bdr
Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1, Michael Bader
MGI ID: MGI:2656492
Synonyms: SM-MHC -
Gene: Myh11  Location: Chr16:14012392-14109227 bp, - strand  Genetic Position: Chr16, 9.71 cM
Alliance: Myh11tm1Bdr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82859
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 5b was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by Northern or Western blot analyses. Expression of non-muscle myosin heavy chain is not affected. (J:82859)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:  94 strains or lines available
References
Original:  J:82859 Morano I, et al., Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol. 2000 Jun;2(6):371-5
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory