Gpc3<tm1Arge> Targeted Allele Detail MGI Mouse (MGI:2657134)

Gpc3^tm1Arge
Targeted Allele Detail

Summary

Symbol:	Gpc3^tm1Arge
Name:	glypican 3; targeted mutation 1, Argiris Efstratiadis
MGI ID:	MGI:2657134
Synonyms:	Gpc3^-, Gpc3^deltaex1
Gene:	Gpc3 Location: ChrX:51361303-51702827 bp, - strand Genetic Position: ChrX, 28.74 cM, cytoband A3.3
Alliance:	Gpc3^tm1Arge page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75054
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Sequence encompassing a portion of the putative promoter region and all of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant embryos at E12.5. (J:75054)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gpc3 Mutation:	18 strains or lines available

References

Original:	J:75054 Chiao E, et al., Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling. Dev Biol. 2002 Mar 1;243(1):185-206
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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