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Jag2tm1Grid
Targeted Allele Detail
Summary
Symbol: Jag2tm1Grid
Name: jagged 2; targeted mutation 1, Tom Gridley
MGI ID: MGI:2657215
Synonyms: Jag2-, Jag2deltaDSL
Gene: Jag2  Location: Chr12:112871439-112893396 bp, - strand  Genetic Position: Chr12, 61.37 cM
Alliance: Jag2tm1Grid page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46930
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of a 5 kb region with a PGK-neo cassette via recombination resulting in deletion of the DSL domain and half of the first EGF repeat. The absence of the DSL domain-containing sequence was confirmed by Southern blot analysis. (J:46930)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jag2 Mutation:  44 strains or lines available
References
Original:  J:46930 Jiang R, et al., Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory