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Nos3tm1Weo
Targeted Allele Detail
Summary
Symbol: Nos3tm1Weo
Name: nitric oxide synthase 3, endothelial cell; targeted mutation 1, William E O'Brien
MGI ID: MGI:2657240
Synonyms: eNOS-, Nos3m
Gene: Nos3  Location: Chr5:24569808-24589472 bp, + strand  Genetic Position: Chr5, 11.32 cM
Alliance: Nos3tm1Weo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51563
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. The gene targeting event results in deletion of the first 54 amino acids and a frameshift of the remaining sequence. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemistry. (J:51563)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nos3 Mutation:  58 strains or lines available
References
Original:  J:51563 Gregg AR, et al., Limb reduction defects in endothelial nitric oxide synthase-deficient mice. Am J Physiol. 1998 Dec;275(6 Pt 2):H2319-24
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory