Mocs1<tm1Jre> Targeted Allele Detail MGI Mouse (MGI:2659140)

Mocs1^tm1Jre
Targeted Allele Detail

Summary

Symbol:	Mocs1^tm1Jre
Name:	molybdenum cofactor synthesis 1; targeted mutation 1, Jochen Reiss
MGI ID:	MGI:2659140
Synonyms:	Moco-deficient, MOCS1 -
Gene:	Mocs1 Location: Chr17:49735390-49762463 bp, + strand Genetic Position: Chr17, 25.45 cM, cytoband C
Alliance:	Mocs1^tm1Jre page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:80807
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette replaced exon 3 and flanking sequences. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:80807)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Mocs1 Mutation:	27 strains or lines available

References

Original:	J:80807 Lee HJ, et al., Molybdenum cofactor-deficient mice resemble the phenotype of human patients. Hum Mol Genet. 2002 Dec 15;11(26):3309-17
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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