Ripk2<tm1Flv> Targeted Allele Detail MGI Mouse (MGI:2660793)

Ripk2^tm1Flv
Targeted Allele Detail

Summary

Symbol:	Ripk2^tm1Flv
Name:	receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:2660793
Synonyms:	Card3 KO, RICK^-, Rip2^-
Gene:	Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
Alliance:	Ripk2^tm1Flv page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75400
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The gene was disrupted by replacement of exons 2 and 3 with a neomycin resistance gene by homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of thymocyte extracts. (J:75400, J:136572)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Ripk2^tm1Flv

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Ripk2 Mutation:	35 strains or lines available

References

Original:	J:75400 Kobayashi K, et al., RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002 Mar 14;416(6877):194-9
All:	68 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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