Slit3<tm1Dor> Targeted Allele Detail MGI Mouse (MGI:2662346)

Slit3^tm1Dor
Targeted Allele Detail

Summary

Symbol:	Slit3^tm1Dor
Name:	slit guidance ligand 3; targeted mutation 1, David M Ornitz
MGI ID:	MGI:2662346
Synonyms:	Slit3^-
Gene:	Slit3 Location: Chr11:35012283-35599334 bp, + strand Genetic Position: Chr11, 20.29 cM, cytoband A5
Alliance:	Slit3^tm1Dor page

Congenital diaphragmatic hernia (CDH) and lung pathology in Slit3^tm1Dor/Slit3^tm1Dor mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:83292
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 3' portion of exon 1 (194 nt) was replaced along with approximately 800 nt of intron 1 by a cassette containing Beta-gal followed by floxed neo. The deleted sequence encoded the putative signal peptide, from the start codon to the first leucine-rich repeat. Endogenous transcript was undetected in homozygous mutant mice by RNase protection. The expression pattern of Beta-gal was similar to that of the endogenous gene. (J:83292)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Slit3 Mutation:	81 strains or lines available

References

Original:	J:83292 Yuan W, et al., A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22
All:	11 reference(s)

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