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Klre1 Gene Detail
Summary
  • Symbol
    Klre1
  • Name
    killer cell lectin-like receptor family E member 1
  • Synonyms
    Klre-1, NKG2I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2662547
    NCBI Gene: 243655
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129554868-129562790 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    428 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2662547
 protein coding gene Chr6:129536329-129562790 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031352
 protein coding gene Chr6:133246781-133255738 (+)
A/J MGP_AJ_G0031323
 protein coding gene Chr6:128152900-128160986 (+)
AKR/J MGP_AKRJ_G0031251
 protein coding gene Chr6:131651165-131659498 (+)
BALB/cJ MGP_BALBcJ_G0031330
 protein coding gene Chr6:127801470-127809431 (+)
C3H/HeJ MGP_C3HHeJ_G0031054
 protein coding gene Chr6:131848489-131856429 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031789
 protein coding gene Chr6:136747813-136755712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028935
 protein coding gene Chr6:126473543-126482057 (+)
CAST/EiJ MGP_CASTEiJ_G0030432
 protein coding gene Chr6:132084001-132093895 (+)
CBA/J MGP_CBAJ_G0031014
 protein coding gene Chr6:142132467-142141788 (+)
DBA/2J MGP_DBA2J_G0031171
 protein coding gene Chr6:127107858-127116556 (+)
FVB/NJ MGP_FVBNJ_G0031121
 protein coding gene Chr6:125991255-125999508 (+)
LP/J MGP_LPJ_G0031251
 protein coding gene Chr6:133467213-133478197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031159
 protein coding gene Chr6:145979716-145987754 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031822
 protein coding gene Chr6:131726053-131733990 (+)
PWK/PhJ MGP_PWKPhJ_G0030150
 protein coding gene Chr6:125388016-125396163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029979
 protein coding gene Chr6:129748082-129756538 (+)
WSB/EiJ MGP_WSBEiJ_G0030520
 protein coding gene Chr6:132148577-132156583 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile and display impaired natural killer cell mediated allogeneic cytotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050241 Ensembl Gene Model | MGI Sequence Detail 7923 C57BL/6J ±  kb
transcript ENSMUST00000053708 Ensembl | MGI Sequence Detail 1294 Not Applicable  
polypeptide ENSMUSP00000055779 Ensembl | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    IPR050919 NKG2/CD94 Natural Killer Receptors
  • GlyGen
    Q8CJC7 1 site
Molecular
Reagents
less
  • All nucleic 4
    Genomic 1
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:83529 Wilhelm BT, et al., Identification of a new murine lectin-like gene in close proximity to CD94. Immunogenetics. 2003 Apr;55(1):53-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory