Muc6 MGI Mouse Gene Detail - MGI:2663233

Muc6 Gene Detail

Symbol

Muc6
Name

mucin 6, gastric

Feature Type

protein coding gene
IDs

MGI:2663233
NCBI Gene: 353328
Alliance

gene page
Transcription Start Sites

34 TSS

Sequence Map

Chr7:141213373-141241641 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.03 cM, cytoband F5
Mapping Data

2 experiments

SNPs within 2kb

496 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2663233	protein coding gene	Chr7:141212404-141241659 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

MUC6, mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MUC6, mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)
Synonyms

MUC-6
Links

HGNC:7517

NCBI Gene ID: 4588

neXtProt AC: NX_Q6W4X9

UniProt: Q6W4X9
Chr Location

11p15.5; chr11:1012823-1036718 (-) GRCh38

MGI Vertebrate Homology

Muc6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MUC6
Gene Tree

Muc6

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

3
Radiation induced

1
Targeted

1
Genomic Mutations

1 involving Muc6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

156 strains or lines available

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All GO Annotations

3
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

4
Tissues

4
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase muc6

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All Sequences

37
RefSeq

20
UniProt

4
CCDS

CCDS90352.1

Ensembl

ENSMUSG00000118661 (Evidence)
NCBI Gene

353328

			Length	Strain/Species	Flank
genomic	ENSMUSG00000118661	Ensembl Gene Model \| MGI Sequence Detail	28269	C57BL/6J	± kb
transcript	ENSMUST00000239500	Ensembl \| MGI Sequence Detail	15593	Not Applicable
polypeptide	ENSMUSP00000159382	Ensembl \| MGI Sequence Detail	4972	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010770 mucin-6

(term hierarchy)
InterPro Domains

IPR006207 Cystine knot, C-terminal

IPR050780 Mucin/von Willebrand/Thrombospondin superfamily

IPR036084 Serine protease inhibitor-like superfamily

IPR002919 Trypsin Inhibitor-like, cysteine rich domain

IPR001846 von Willebrand factor, type D domain

IPR001007 VWFC domain

IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
GlyGen

Q80T03 6 sites, 4 N-linked glycans (4 sites)

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 6
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:314694 Douchi D, et al., Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus. Gastroenterology. 2021 Dec;161(6):1907-1923.e26

TSS for Muc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75705	Chr7:141241637-141241643 (-)	1 bp
Tssr75704	Chr7:141226576-141226590 (-)	15,058 bp
Tssr75703	Chr7:141226371-141226384 (-)	15,263 bp
Tssr75702	Chr7:141226348-141226358 (-)	15,288 bp
Tssr75701	Chr7:141226259-141226282 (-)	15,370 bp
Tssr75700	Chr7:141226240-141226251 (-)	15,395 bp
Tssr75699	Chr7:141226208-141226217 (-)	15,428 bp
Tssr75697	Chr7:141220234-141220261 (-)	21,393 bp
Tssr75696	Chr7:141219791-141219807 (-)	21,842 bp
Tssr75695	Chr7:141219777-141219784 (-)	21,860 bp
Tssr75693	Chr7:141218707-141218721 (-)	22,927 bp
Tssr75692	Chr7:141217944-141217961 (-)	23,688 bp
Tssr75691	Chr7:141217929-141217938 (-)	23,707 bp
Tssr75690	Chr7:141217772-141217789 (-)	23,860 bp
Tssr75689	Chr7:141217660-141217694 (-)	23,964 bp
Tssr75688	Chr7:141217645-141217657 (-)	23,990 bp
Tssr75687	Chr7:141217582-141217605 (-)	24,047 bp
Tssr2449	Chr7:141217385-141217399 (-)	24,249 bp
Tssr75686	Chr7:141217297-141217302 (-)	24,341 bp
Tssr75685	Chr7:141217275-141217282 (-)	24,362 bp
Tssr2448	Chr7:141217179-141217187 (-)	24,458 bp
Tssr75684	Chr7:141217159-141217164 (-)	24,479 bp
Tssr75683	Chr7:141217143-141217150 (-)	24,494 bp
Tssr75682	Chr7:141217121-141217138 (-)	24,511 bp
Tssr75681	Chr7:141217062-141217089 (-)	24,565 bp
Tssr75680	Chr7:141217030-141217050 (-)	24,601 bp
Tssr75679	Chr7:141216989-141217017 (-)	24,638 bp
Tssr75678	Chr7:141216949-141216958 (-)	24,687 bp
Tssr75677	Chr7:141216845-141216858 (-)	24,789 bp
Tssr75676	Chr7:141216793-141216823 (-)	24,833 bp
Tssr75675	Chr7:141216781-141216790 (-)	24,855 bp
Tssr75674	Chr7:141216712-141216719 (-)	24,925 bp
Tssr75673	Chr7:141216652-141216657 (-)	24,986 bp
Tssr75672	Chr7:141216526-141216536 (-)	25,110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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