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Bcl11btm1Jpk
Targeted Allele Detail
Summary
Symbol: Bcl11btm1Jpk
Name: B cell leukemia/lymphoma 11B; targeted mutation 1, Japan Kominami
MGI ID: MGI:2663971
Synonyms: Bcl11b-
Gene: Bcl11b  Location: Chr12:107876662-107969861 bp, - strand  Genetic Position: Chr12, 59.1 cM, cytoband F1
Alliance: Bcl11btm1Jpk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83651
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 1 via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of thymus proteins from homozygous mutant animals. (J:83651)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 186 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bcl11b Mutation:  46 strains or lines available
References
Original:  J:83651 Wakabayashi Y, et al., Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory