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Cnga4 Gene Detail
Summary
  • Symbol
    Cnga4
  • Name
    cyclic nucleotide gated channel alpha 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664099
    NCBI Gene: 233649
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:105053775-105057949 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664099
 protein coding gene Chr7:105049247-105057981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032751
 protein coding gene Chr7:108648568-108652738 (+)
A/J MGP_AJ_G0032731
 protein coding gene Chr7:105811591-105815761 (+)
AKR/J MGP_AKRJ_G0032664
 protein coding gene Chr7:108574815-108581686 (+)
BALB/cJ MGP_BALBcJ_G0032737
 protein coding gene Chr7:105528197-105532367 (+)
C3H/HeJ MGP_C3HHeJ_G0032446
 protein coding gene Chr7:108673407-108677577 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033242
 protein coding gene Chr7:112965456-112969626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030226
 protein coding gene Chr7:107790514-107794695 (+)
CAST/EiJ MGP_CASTEiJ_G0031776
 protein coding gene Chr7:100496533-100501439 (+)
CBA/J MGP_CBAJ_G0032420
 protein coding gene Chr7:116746424-116750594 (+)
DBA/2J MGP_DBA2J_G0032573
 protein coding gene Chr7:104082515-104086685 (+)
FVB/NJ MGP_FVBNJ_G0032526
 protein coding gene Chr7:103888240-103892411 (+)
LP/J MGP_LPJ_G0032664
 protein coding gene Chr7:110052322-110056492 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032558
 protein coding gene Chr7:118355535-118359705 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033263
 protein coding gene Chr7:107624839-107629010 (+)
PWK/PhJ MGP_PWKPhJ_G0031489
 protein coding gene Chr7:97009408-97018256 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031338
 protein coding gene Chr7:94743031-94747211 (+)
WSB/EiJ MGP_WSBEiJ_G0031893
 protein coding gene Chr7:108268408-108272579 (+)



Homology
more
  • Human Ortholog
    CNGA4, cyclic nucleotide gated channel subunit alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNGA4, cyclic nucleotide gated channel subunit alpha 4
  • Synonyms
    CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCb, OCNCBETA
  • Links
    NCBI Gene ID: 1262
    neXtProt AC: NX_Q8IV77
    UniProt: Q8IV77

  • Chr Location
    11p15.4; chr11:6234765-6244976 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in odor adaptation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030897 Ensembl Gene Model | MGI Sequence Detail 4175 C57BL/6J ±  kb
    transcript ENSMUST00000033187 Ensembl | MGI Sequence Detail 2484 Not Applicable  
    polypeptide ENSMUSP00000033187 Ensembl | MGI Sequence Detail 575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005631 cyclic nucleotide-gated cation channel alpha-4
      (term hierarchy)
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR050866 Cyclic Nucleotide-Gated Cation Channel
      IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
      IPR005821 Ion transport domain
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:179991 Cisneros-Mejorado A, et al., cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. FEBS Lett. 2012 Jan 20;586(2):149-53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory