Psen2<tm1Haa> Targeted Allele Detail MGI Mouse (MGI:2664242)

Psen2^tm1Haa
Targeted Allele Detail

Summary

Symbol:	Psen2^tm1Haa
Name:	presenilin 2; targeted mutation 1, Christian Haass
MGI ID:	MGI:2664242
Synonyms:	PS2^-
Gene:	Psen2 Location: Chr1:180054569-180091003 bp, - strand Genetic Position: Chr1, 84.19 cM
Alliance:	Psen2^tm1Haa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:83860
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 5 via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis of brain lysates from homozygous mutant animals. (J:83860)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

52043 assay results
4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Psen2 Mutation:	32 strains or lines available

References

Original:	J:83860 Steiner H, et al., A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem. 1999 Oct 1;274(40):28669-73
All:	41 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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