Prkcq<tm1Litt> Targeted Allele Detail MGI Mouse (MGI:2664379)

Prkcq^tm1Litt
Targeted Allele Detail

Summary

Symbol:	Prkcq^tm1Litt
Name:	protein kinase C, theta; targeted mutation 1, Dan Littman
MGI ID:	MGI:2664379
Synonyms:	PKCtheta^-, PKC-Theta^-
Gene:	Prkcq Location: Chr2:11176922-11306033 bp, + strand Genetic Position: Chr2, 8.42 cM
Alliance:	Prkcq^tm1Litt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:83922
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The exon encoding the ATP-binding site of the kinase domain (aa 396 - 451) was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in thymocytes or T cells obtained from mutant mice. (J:83922)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Prkcq Mutation:	51 strains or lines available

References

Original:	J:83922 Sun Z, et al., PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23;404(6776):402-7
All:	86 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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