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Tmod2tm1Hzo
Targeted Allele Detail
Summary
Symbol: Tmod2tm1Hzo
Name: tropomodulin 2; targeted mutation 1, Huda Y Zoghbi
MGI ID: MGI:2664500
Synonyms: A12, Tmod2lacZ-
Gene: Tmod2  Location: Chr9:75472903-75518607 bp, - strand  Genetic Position: Chr9, 42.31 cM
Alliance: Tmod2tm1Hzo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83752
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 was deleted and replaced with an in-frame lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of brain proteins from homozygous mutant animals. (J:83752)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmod2 Mutation:  18 strains or lines available
References
Original:  J:83752 Cox PR, et al., Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory. Mol Cell Neurosci. 2003 May;23(1):1-12
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory