Trpv4<tm1Msz> Targeted Allele Detail MGI Mouse (MGI:2667379)

Trpv4^tm1Msz
Targeted Allele Detail

Summary

Symbol:	Trpv4^tm1Msz
Name:	transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, Makoto Suzuki
MGI ID:	MGI:2667379
Synonyms:	Trpv4^-, TRPV4KO
Gene:	Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
Alliance:	Trpv4^tm1Msz page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:84093
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance gene was inserted into exon 4 which encodes the ankyrin-repeat domain. Transcripts were undetectable by RT-PCR and Northern blot in trigeminal root and dorsal root ganglia of homozygous animals. Immunohistochemical staining of the dorsal root ganglion confirmed the success of gene disruption. (J:84093)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Trpv4 Mutation:	57 strains or lines available

References

Original:	J:84093 Suzuki M, et al., Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8
All:	92 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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