Celsr1<Crsh> Chemically induced Allele Detail MGI Mouse (MGI:2668337)

Celsr1^Crsh
Chemically induced Allele Detail

Summary

Symbol:	Celsr1^Crsh
Name:	cadherin, EGF LAG seven-pass G-type receptor 1; crash
MGI ID:	MGI:2668337
Synonyms:	MUT1494
Gene:	Celsr1 Location: Chr15:85783130-85918404 bp, - strand Genetic Position: Chr15, 40.42 cM
Alliance:	Celsr1^Crsh page

Mutation
origin

Strain of Origin:

(C3H/HeH x 101/H)F1

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A A-to-G point mutation at nucleotide 3126 was induced by ENU mutagenesis. The mutation results in an aspartate to glycine substitution at codon 1040, which lies within the eighth cadherin repeat of the extracellular domain. Western blot analysis indicates no difference in abundance of protein. (J:84285, J:216413)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Celsr1 Mutation:	146 strains or lines available

References

Original:	J:84285 Curtin JA, et al., Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 2003 Jul 1;13(13):1129-33
All:	19 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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