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Nodaltm4Rob
Targeted Allele Detail
Summary
Symbol: Nodaltm4Rob
Name: nodal growth differentiation factor; targeted mutation 4, Elizabeth J Robertson
MGI ID: MGI:2668418
Synonyms: NodaldeltaPEE
Gene: Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Alliance: Nodaltm4Rob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84300
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified regulatory region)
Mutation:    Other
 
Mutation details: A hypomorphic allele was generated by the deletion of the proximal epiblast enhancer (PEE), a 2 kb element located about 10 kb upstream of the first exon. The PEE element was initially replaced with a floxed PGK-hygro cassette that was subsequently removed in vitro, leaving a single loxP in its place. (J:84300)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  42 strains or lines available
References
Original:  J:84300 Vincent SD, et al., Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003 Jul 1;17(13):1646-62
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory