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Ilktm1Star
Targeted Allele Detail
Summary
Symbol: Ilktm1Star
Name: integrin linked kinase; targeted mutation 1, Rene St-Arnaud
MGI ID: MGI:2668459
Synonyms: ILKfl, ILKflox, ILK(lox), ilkloxP
Gene: Ilk  Location: Chr7:105385799-105392132 bp, + strand  Genetic Position: Chr7, 55.97 cM, cytoband E1
Alliance: Ilktm1Star page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84273
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: LoxP sites were inserted downstream of exon 4 and exon 12 (along with a neomycin resistance gene cassette). (J:84273)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 26 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 18 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ilk Mutation:  18 strains or lines available
References
Original:  J:84273 Terpstra L, et al., Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol. 2003 Jul 7;162(1):139-48
All:  61 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory