Hoxb1tm6(cre)Mrc
Targeted Allele Detail
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| Symbol: |
Hoxb1tm6(cre)Mrc |
| Name: |
homeobox B1; targeted mutation 6, Mario R Capecchi |
| MGI ID: |
MGI:2668513 |
| Synonyms: |
Hoxb1-Ires-Cre |
| Gene: |
Hoxb1 Location: Chr11:96256578-96259082 bp, + strand Genetic Position: Chr11, 59.86 cM
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| Alliance: |
Hoxb1tm6(cre)Mrc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:84448
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Hoxb1tm6(cre)Mrc expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Hoxb1 (MGI:96182) |
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Mutation details: An IRES-Cre cassette containing a neomycin selection gene flanked with frt sites was introduced into the 3' untranslated region downstream of the translational stop codon and upstream of the endogenous polyadenylation signal. Crossing with a flp deleter line to excise the neomycin resistance gene resulted in animals able to express Cre from the Hoxb1 locus without interfering with endogenous Hoxb1 activity.
(J:84448)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Hoxb1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hoxb1 Mutation: |
24 strains or lines available
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Cre expression under the control of the Hoxb1 promoter was used to activate reporter genes in the descendants of rhombomere 4-derived neural crest cells (r4).
- first expressed at E7 in the caudal primitive streak in mesodermal somites and caudal tail
- by 10-11 somite stage reporter activity is found in ectodermal cells of r4
- by E10.5 caudal mesoderm derivatives are found throughout the embryonic trunk and limbs extending rostrally to the caudal hindbrain
- at E11.5 cells are found in the neuroepithelium and 2nd branchial arch
- by E14.5, cells are found throughout the embryo
- in cartilage and bone of the neck and external ear
- cells of the tongue, salivary gland, pterygopalatine ganglia
- cell bodies and axon tracts of the facial nerve (VII)
- CNS localization is primarily to the 7th and 8th sensory ganglion complex and the 7th cranial nerve
- motor neurons of the facial nerve
- glial cells
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| Original: |
J:84448 Arenkiel BR, et al., Hoxb1 neural crest preferentially form glia of the PNS. Dev Dyn. 2003 Jul;227(3):379-86 |
| All: |
20 reference(s) |
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Analysis Tools