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Hprt1tm2Detl
Targeted Allele Detail
Summary
Symbol: Hprt1tm2Detl
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Peter J Detloff
MGI ID: MGI:2668517
Synonyms: hprtNLSQ150
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm2Detl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84451
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Disruption caused by insertion of vector, Insertion
 
Mutation details: Exon 3 was disrupted by the insertion of a cassette containing a nuclear localization signal (NLS), myc tag, and 150 CAG repeats encoding 150 glutamine residues. (J:84451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:84451 Jackson WS, et al., Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet. 2003 Jul 1;12(13):1621-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory