Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Neurod6tm1(cre)Kan
Name:	neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
MGI ID:	MGI:2668659
Synonyms:	Math2/Cre, Neurod6-cre, Neurod6/Cre, NexCre, NEX-Cre
Gene:	Neurod6  Location: Chr6:55654807-55658248 bp, - strand  Genetic Position: Chr6, 27.53 cM
Alliance:	Neurod6tm1(cre)Kan page

Germline Transmission:	Earliest citation of germline transmission: J:62118
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Neurod6tm1(cre)Kan expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Neurod6 (MGI:106593)   Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing cre recombinase followed by a neomycin resistance gene in exon 2. The endogenous promoter drove expression of cre in the granule cells of the hippocampus. (J:62118, J:117061)

Activity:	Tissue activity of this recombinase allele
Driver:	Neurod6 (mouse) Summary of all recombinase alleles driven by Neurod6. Comparative matrix view of recombinase activities Alliance mouse Neurod6 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

61 assay results 10 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurod6 Mutation:	18 strains or lines available

Original:	J:62118 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci. 2000 May 15;20(10):3714-24
All:	325 reference(s)