Tg(Itga2b-cre)NE1/21Emam
Transgene Detail
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| Symbol: |
Tg(Itga2b-cre)NE1/21Emam |
| Name: |
transgene insertion NE1/21, Nikla R Emambokus |
| MGI ID: |
MGI:2670207 |
| Synonyms: |
gpIIb-Cre |
| Transgene: |
Tg(Itga2b-cre)NE1/21Emam Location: unknown
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| Alliance: |
Tg(Itga2b-cre)NE1/21Emam page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Itga2b-cre)NE1/21Emam expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Itga2b |
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Mutation details: The transgenic construct was comprised of an integrin alpha 2b genomic fragment, including 2.5 kb of promoter through 2.8 kb of intron 1, adjoined to sequence encoding cre recombinase with a nuclear localization signal. The cassette containng NLS-cre also contained a splice acceptor site, IRES, and a polyadenylation signal. The integrin alpha 2b promoter drives expression of cre recombinase at the site of emergence of hematopoietic progenitors in the yolk sac, aorta-gonad-mesonephros region, and fetal liver. Founder mice contained between 2 and 5 copies of the transgene.
(J:84564)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Itga2b
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:84564 Emambokus NR, et al., The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity. 2003 Jul;19(1):33-45 |
| All: |
2 reference(s) |
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Analysis Tools
