Rgn<tm1Aish> Targeted Allele Detail MGI Mouse (MGI:2670511)

Rgn^tm1Aish
Targeted Allele Detail

Summary

Symbol:	Rgn^tm1Aish
Name:	regucalcin; targeted mutation 1, Akihito Ishigami
MGI ID:	MGI:2670511
Synonyms:	SMP30 -, SMP30/GNL knockout
Gene:	Rgn Location: ChrX:20416026-20428328 bp, + strand Genetic Position: ChrX, 16.04 cM
Alliance:	Rgn^tm1Aish page

Osteogenic disorder in vitamin C-deficient Rgn^tm1Aish/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:79342
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Exon III was disrupted by the insertion of a neomycin gene. The absence of gene product was proven by Western blot analysis of liver extracts from hemizygous males and homozygous females. (J:79342)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rgn Mutation:	5 strains or lines available

References

Original:	J:79342 Ishigami A, et al., Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-alpha- and Fas-Mediated Apoptosis. Am J Pathol. 2002 Oct;161(4):1273-81
All:	32 reference(s)

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