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Pdgfbtm3.1Cbet
Targeted Allele Detail
Summary
Symbol: Pdgfbtm3.1Cbet
Name: platelet derived growth factor, B polypeptide; targeted mutation 3.1, Christer Betsholtz
MGI ID: MGI:2670574
Synonyms: pdgf-bret, pdgfbret
Gene: Pdgfb  Location: Chr15:79880075-79899178 bp, - strand  Genetic Position: Chr15, 37.85 cM, cytoband E
Alliance: Pdgfbtm3.1Cbet page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84701
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The floxed neo cassette was removed from intron 5 of Pdgfbtm3Cbet via in vivo cre mediated recombination. The stop codon that was inserted into exon 6 remained intact and precluded the translation of the retention motif. (J:84701)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 16 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfb Mutation:  15 strains or lines available
References
Original:  J:84701 Lindblom P, et al., Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev. 2003 Aug 1;17(15):1835-40
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory