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Pglyrp1tm1Rdz
Targeted Allele Detail
Summary
Symbol: Pglyrp1tm1Rdz
Name: peptidoglycan recognition protein 1; targeted mutation 1, Roman Dziarski
MGI ID: MGI:2670590
Synonyms: PGRP-S-
Gene: Pglyrp1  Location: Chr7:18618615-18624363 bp, + strand  Genetic Position: Chr7, 9.38 cM, cytoband A3
Alliance: Pglyrp1tm1Rdz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84680
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 was replaced with a cassette containing IRES-lacZ and neo. Transcript and protein were undetected in homozygous mutant mice by RT-PCR and Western blot analyses of bone marrow. (J:84680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pglyrp1 Mutation:  15 strains or lines available
References
Original:  J:84680 Dziarski R, et al., Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. Blood. 2003 Jul 15;102(2):689-97
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory