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Hnf1btm3Mya
Targeted Allele Detail
Summary
Symbol: Hnf1btm3Mya
Name: HNF1 homeobox B; targeted mutation 3, Moshe Yaniv
MGI ID: MGI:2670936
Synonyms: Hnf1betaflox
Gene: Hnf1b  Location: Chr11:83741035-83796743 bp, + strand  Genetic Position: Chr11, 51.23 cM
Alliance: Hnf1btm3Mya page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75935
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus by homologous recombination. The neomycin selection cassette was deleted in ES cells by transient expression of Cre recombinase, resulting in loxP sites flanking the promoter region, the transcription initiation site, and exon 1 in the final allele. (J:75935)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:  16 strains or lines available
References
Original:  J:75935 Coffinier C, et al., Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. Development. 2002 Apr;129(8):1829-38
All:  21 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory