Rdx<tm1Sts> Targeted Allele Detail MGI Mouse (MGI:2671151)

Rdx^tm1Sts
Targeted Allele Detail

Summary

Symbol:	Rdx^tm1Sts
Name:	radixin; targeted mutation 1, Shoichiro Tsukita
MGI ID:	MGI:2671151
Synonyms:	Rdx-
Gene:	Rdx Location: Chr9:51958450-52000038 bp, + strand Genetic Position: Chr9, 28.62 cM
Alliance:	Rdx^tm1Sts page

Stereocilia abnormalities on Rdx^tm1Sts/Rdx^tm1Sts cochlear hair cells of adult and newborn mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:77485
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment including exon 3 was replaced with a cassette containing a spice acceptor sie, an internal ribosomal entry site followed by a lacZ gene, and a neomycin selection gene. Western blot analysis of kidney and liver proteins derived from homozygous mice demonstrated that no detectable protein was made from this allele. (J:77485)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rdx Mutation:	47 strains or lines available

References

Original:	J:77485 Kikuchi S, et al., Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002 Jul;31(3):320-5
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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