Runx1t1tm1Buch
Targeted Allele Detail
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| Symbol: |
Runx1t1tm1Buch |
| Name: |
RUNX1 translocation partner 1; targeted mutation 1, Frank Buchholz |
| MGI ID: |
MGI:2671472 |
| Synonyms: |
ETOX |
| Gene: |
Runx1t1 Location: Chr4:13743436-13893649 bp, + strand Genetic Position: Chr4, 5.88 cM, cytoband A
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| Alliance: |
Runx1t1tm1Buch page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:68499
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Humanized sequence) |
| Mutation: |
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Other
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Mutation details: A floxed neo cassette was inserted into intron 1, 893 bp upstream of exon 2. This allele, in combination with allele Runx1tm1Buch in the same cells was used for the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21).
(J:68499)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Runx1t1 Mutation: |
37 strains or lines available
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| Original: |
J:68499 Buchholz F, et al., Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug;1(2):133-9 |
| All: |
1 reference(s) |
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Analysis Tools
