Disp1<tm1Pab> Targeted Allele Detail MGI Mouse (MGI:2672101)

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Disp1^tm1Pab
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Disp1^tm1Pab
Name:	dispatched RND transporter family member 1; targeted mutation 1, Philip A Beachy
MGI ID:	MGI:2672101
Synonyms:	mDispA-
Gene:	Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
Alliance:	Disp1^tm1Pab page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:79457
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 7, the last coding exon, was replaced with a floxed neo cassette inserted by homolgous recombination. The deleted exon encoded 78% of the coding sequence (1193 of 1521 codons), including 11 of the 12 transmembrane domains. (J:79457)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Disp1 Mutation:	61 strains or lines available

References

Original:	J:79457 Ma Y, et al., Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched. Cell. 2002 Oct 4;111(1):63
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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