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Gata2tm1Mym
Targeted Allele Detail
Summary
Symbol: Gata2tm1Mym
Name: GATA binding protein 2; targeted mutation 1, Masayuki Yamamoto
MGI ID: MGI:2673268
Synonyms: EII-KI, Gata2gfp
Gene: Gata2  Location: Chr6:88170873-88184014 bp, + strand  Genetic Position: Chr6, 39.2 cM
Alliance: Gata2tm1Mym page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84836
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Sequence encoding green fluorescent protein (GFP) was inserted into exon 2, replacing the first coding exon. A loxP site flanked neomycin resistance gene cassette that was included in the initial targeting vector was removed via cre-mediated recombination.The profile of GFP expression was consistent with that of the endogenous expression. (J:84836, J:106045)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 90 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:  30 strains or lines available
References
Original:  J:84836 Minegishi N, et al., Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood. 2003 Aug 1;102(3):896-905
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory