Nod1tm1Inoh
Targeted Allele Detail
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| Symbol: |
Nod1tm1Inoh |
| Name: |
nucleotide-binding oligomerization domain containing 1; targeted mutation 1, Naohiro Inohara |
| MGI ID: |
MGI:2674231 |
| Synonyms: |
Nod1- |
| Gene: |
Nod1 Location: Chr6:54900934-54949597 bp, - strand Genetic Position: Chr6, 27.22 cM
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| Alliance: |
Nod1tm1Inoh page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:85240
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| Parent Cell Line: |
E14K (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 1 and 2 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the CARD domain which is essential for Ripk2 binding and Nfkb1 activation. Transcript was undetected by RT-PCR analysis of cells obtained from homozygous mutant mice.
(J:85240)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:85240 Chamaillard M, et al., An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003 Jul;4(7):702-7 |
| All: |
43 reference(s) |
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Analysis Tools
