Jak3<tm1Jni> Targeted Allele Detail MGI Mouse (MGI:2675061)

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Jak3^tm1Jni
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Jak3^tm1Jni
Name:	Janus kinase 3; targeted mutation 1, James N Ihle
MGI ID:	MGI:2675061
Synonyms:	Jak3 -
Gene:	Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
Alliance:	Jak3^tm1Jni page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:29723
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A hygromycin selection gene was inserted into the first coding exon. No encoded protein was detected in extracts derived from spleen, thymus, or bone marrow. (J:29723)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Jak3 Mutation:	84 strains or lines available

References

Original:	J:29723 Nosaka T, et al., Defective lymphoid development in mice lacking Jak3. Science. 1995 Nov 3;270(5237):800-2
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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