Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptch1tm1Bjw
Name:	patched 1; targeted mutation 1, Brandon J Wainwright
MGI ID:	MGI:2675356
Synonyms:	Ptc1lox, Ptch1c, Ptch1flox, Ptch1neo
Gene:	Ptch1  Location: Chr13:63656142-63721274 bp, - strand  Genetic Position: Chr13, 32.8 cM
Alliance:	Ptch1tm1Bjw page

Germline Transmission:	Earliest citation of germline transmission: J:85040
Parent Cell Line:	C1368 (ES Cell)
Strain of Origin:	129T2/SvEms

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 3 was flanked by a single upstream loxP site in intron 2 and an FRT-neo-FRT-loxP cassette in intron 3. Mice carrying this allele were used to generate Ptchtm1.1Bjw. (J:85040)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	76 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptch1tm1Bjw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:	115 strains or lines available

Original:	J:85040 Ellis T, et al., Patched 1 conditional null allele in mice. Genesis. 2003 Jul;36(3):158-61
All:	78 reference(s)