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Gp6tm1Ware
Targeted Allele Detail
Summary
Symbol: Gp6tm1Ware
Name: glycoprotein 6 platelet; targeted mutation 1, Jerry Ware
MGI ID: MGI:2675830
Synonyms: GP VI-, GPVI-
Gene: Gp6  Location: Chr7:4366964-4400743 bp, - strand  Genetic Position: Chr7, 2.52 cM
Alliance: Gp6tm1Ware page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85315
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A stop codon and neomycin resistance cassette were inserted in exon 1 immediately 3 prime to the start codon. Platelet lysates from mice homozygous for this mutation lacked protein product as determined immunologically. (J:85315)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gp6 Mutation:  19 strains or lines available
Notes
ES cell line = DS2A.
References
Original:  J:85315 Kato K, et al., The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood. 2003 Sep 1;102(5):1701-7
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory