Bad<tm1Sjk> Targeted Allele Detail MGI Mouse (MGI:2675966)

Bad^tm1Sjk
Targeted Allele Detail

Summary

Symbol:	Bad^tm1Sjk
Name:	BCL2-associated agonist of cell death; targeted mutation 1, Stanley J Korsmeyer
MGI ID:	MGI:2675966
Synonyms:	Bad^-
Gene:	Bad Location: Chr19:6919229-6929267 bp, + strand Genetic Position: Chr19, 5.1 cM
Alliance:	Bad^tm1Sjk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:84987
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 3 kb stretch of DNA containing both exon 3 which contains the BH3 domain and exon 4 which contains the polyadenylation signal was replaced by a neomycin resistance cassette. Western blot analysis demonstrated absence of both the long and the short protein products. (J:84987)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Bad^tm1Sjk

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Bad Mutation:	25 strains or lines available

References

Original:	J:84987 Ranger AM, et al., Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9324-9
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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