Lgmn<tm1Ihn> Targeted Allele Detail MGI Mouse (MGI:2676125)

Lgmn^tm1Ihn
Targeted Allele Detail

Summary

Symbol:	Lgmn^tm1Ihn
Name:	legumain; targeted mutation 1, Ikuko Hara-Nishimura
MGI ID:	MGI:2676125
Synonyms:	AEP^-
Gene:	Lgmn Location: Chr12:102360341-102405987 bp, - strand Genetic Position: Chr12, 51.45 cM
Alliance:	Lgmn^tm1Ihn page

Enlargement of lysosomes in the kidney-proximal tubule cells of Lgmn^tm1Ihn/Lgmn^tm1Ihn mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:85207
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: 3 exons were flanked by loxP sites and excised prior to germline transmission via cre-mediated recombination. An frt-flanked neo cassette was left in an intron. Neither transcript nor protein was detected in homozygous mutant mice by RT-PCR and Western blot analyses of kidney tissue. (J:85207)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lgmn Mutation:	35 strains or lines available

References

Original:	J:85207 Shirahama-Noda K, et al., Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9
All:	21 reference(s)

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