About   Help   FAQ
Plekhg1 Gene Detail
Summary
  • Symbol
    Plekhg1
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 1
  • Synonyms
    D10Ertd733e, mKIAA1209
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676551
    NCBI Gene: 213783
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:3690364-3917303 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6448 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676551
 protein coding gene Chr10:3690206-3917303 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016974
 protein coding gene Chr10:670503-918708 (+)
A/J MGP_AJ_G0016952
 protein coding gene Chr10:644819-884332 (+)
AKR/J MGP_AKRJ_G0016917
 protein coding gene Chr10:615331-858179 (+)
BALB/cJ MGP_BALBcJ_G0016910
 protein coding gene Chr10:615025-846066 (+)
C3H/HeJ MGP_C3HHeJ_G0016735
 protein coding gene Chr10:688778-932648 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017373
 protein coding gene Chr10:664706-915501 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015079
 protein coding gene Chr10:502584-722300 (+)
CAST/EiJ MGP_CASTEiJ_G0016317
 protein coding gene Chr10:716106-959190 (+)
CBA/J MGP_CBAJ_G0016707
 protein coding gene Chr10:664700-925689 (+)
DBA/2J MGP_DBA2J_G0016815
 protein coding gene Chr10:657794-884300 (+)
FVB/NJ MGP_FVBNJ_G0016810
 protein coding gene Chr10:611343-840199 (+)
LP/J MGP_LPJ_G0016890
 protein coding gene Chr10:675197-928237 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016841
 protein coding gene Chr10:671669-909894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017410
 protein coding gene Chr10:630885-869765 (+)
PWK/PhJ MGP_PWKPhJ_G0016103
 protein coding gene Chr10:641188-877748 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015884
 protein coding gene Chr10:817536-1063109 (+)
WSB/EiJ MGP_WSBEiJ_G0016378
 protein coding gene Chr10:659585-905548 (+)



Homology
more
  • Human Ortholog
    PLEKHG1, pleckstrin homology and RhoGEF domain containing G1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG1, pleckstrin homology and RhoGEF domain containing G1
  • Synonyms
    ARHGEF41
  • Links
    NCBI Gene ID: 57480
    neXtProt AC: NX_Q9ULL1
    UniProt: Q9ULL1

  • Chr Location
    6q25.1; chr6:150599883-150843665 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    11
  • cDNA Data
    17
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040624 Ensembl Gene Model | MGI Sequence Detail 226940 C57BL/6J ±  kb
    transcript ENSMUST00000239159 Ensembl | MGI Sequence Detail 4478 Not Applicable  
    polypeptide ENSMUSP00000159056 Ensembl | MGI Sequence Detail 1465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR011993 PH-like domain superfamily
      IPR043324 PKHG1/2/3, pleckstrin homology (PH) domain
      IPR001849 Pleckstrin homology domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289304
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 7
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:352993 Krishnamurthy A, et al., Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival. Development. 2024 Jul 15;151(14):dev202502
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory