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Zap70tm1Dlo
Targeted Allele Detail
Summary
Symbol: Zap70tm1Dlo
Name: zeta-chain (TCR) associated protein kinase; targeted mutation 1, Dennis Y Loh
MGI ID: MGI:2677447
Synonyms: ZAP-70 -
Gene: Zap70  Location: Chr1:36800912-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance: Zap70tm1Dlo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27768
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced the entire coding region of the gene. Western blot analysis demonstrated that no detectable protein product was produced from this allele. (J:27768)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:  55 strains or lines available
References
Original:  J:27768 Negishi I, et al., Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature. 1995 Aug 3;376(6539):435-8
All:  25 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory