Nkx2-1tm1Jaw
Targeted Allele Detail
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| Symbol: |
Nkx2-1tm1Jaw |
| Name: |
NK2 homeobox 1; targeted mutation 1, Jeffrey A Whitsett |
| MGI ID: |
MGI:2677488 |
| Synonyms: |
Titf1PM |
| Gene: |
Nkx2-1 Location: Chr12:56578741-56583570 bp, - strand Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
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| Alliance: |
Nkx2-1tm1Jaw page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:85424
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence encoding S80, a phosphorylation mutant allele of the orthologous rat gene in which 7 serine codons are replaced with alanine codons, was inserted in place of a fragment extending from the start codon (bp 7957) to the end of the homeobox (bp 9480). A polyadenylation signal and neo cassette were included immediately downstream of S80. Southern blot analysis confirmed the integration of the mutation that putatively produces a protein lacking residues required for phosphorylation.
(J:85424)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nkx2-1 Mutation: |
24 strains or lines available
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ES cell line = MPI1 (MPI-I).
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| Original: |
J:85424 DeFelice M, et al., TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003 Sep 12;278(37):35574-83 |
| All: |
3 reference(s) |
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Analysis Tools
