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Ncor1tm1Rsd
Targeted Allele Detail
Summary
Symbol: Ncor1tm1Rsd
Name: nuclear receptor co-repressor 1; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:2677822
Synonyms: N-CoR -
Gene: Ncor1  Location: Chr11:62207132-62348200 bp, - strand  Genetic Position: Chr11, 38.08 cM, cytoband B2
Alliance: Ncor1tm1Rsd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65417
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced a 3 kb genomic fragment containing the coding sequences for the Sin3 interaction domain. Western blot analysis on lysates derived from MEFs of homozygous mice demonstrated that no detectable protein was produced from this allele. (J:65417)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor1 Mutation:  396 strains or lines available
References
Original:  J:65417 Jepsen K, et al., Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15;102(6):753-63
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory