Hif1a<tm1Stom> Targeted Allele Detail MGI Mouse (MGI:2677892)

Hif1a^tm1Stom
Targeted Allele Detail

Summary

Symbol:	Hif1a^tm1Stom
Name:	hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Shuhei Tomita
MGI ID:	MGI:2677892
Synonyms:	Hif-1alpha^F, Hif-1alpha^flox
Gene:	Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
Alliance:	Hif1a^tm1Stom page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:85763
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Exons 13, 14, and 15 were flanked by single loxP sites. The floxed region encodes the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. (J:85763)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Hif1a^tm1Stom

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hif1a Mutation:	50 strains or lines available

References

Original:	J:85763 Tomita S, et al., Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct;23(19):6739-49
All:	40 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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